The Centre for HIV-AIDS Prevention Studies

Community-Led, Community-Loved, Community Trusted

Research

CHAPS evolved from the Orange Farm research programme and team that, in the 5 years prior to 2010, had researched and published extensively around the topic of voluntary medical male circumcision. The research and the publications of the Orange Farm team, most notably the randomised controlled trial which demonstrated the 60% protective benefit of medical male circumcision, contributed to the World Health Organization (WHO) recommendations in 2007.

Today, CHAPS is most recognised for its biomedical research and community-based research in the scale-up of voluntary medical male circumcision (VMMC) for HIV prevention in South Africa and the region. However, with both programmatic and research expertise, we are able to offer community-based research and feasibility studies in a number of areas.

Our expertise includes efficient clinical scale-up and social uptake of services in multiple public health priority areas. With resident clinical trial expertise, and an in-depth knowledge of regulatory frameworks and GCP principles, coupled with access to clinics and laboratories, CHAPS is ideally placed to undertake all spheres of research with high standards.

  • VMMC Randomized Control Trial – Orange Farm (2002-2005)
  • Community Impact of VMMC Study – Orange Farm (2007-2010)
  • SYMMACS Study (2011-2012)
  • Demand Creation Study (2012)
  • EIMC Acceptability Study (2013)
  • Training Follow-up Study (2013)
  • A Case Series, Non-Comparative Study in South Africa: CircumQ (2014-2015)
  • The Randomized Control Trial for CircumQ Surgical Aid (2015 – 2016)
  • HIV Self-testing Kit Study (2014- 2015)
  • Prepex Study (2014-2017)
  • TB / Health Survey (2000)
  • EIMC Pilot Study (2015-2017)

Research, Publications And Conference Presentations

2017

CHAPS Linkage to Care Programme (M170278)

Increasing the uptake of HIV Testing through self-testing kits to ensure that by 2020, 90% of all people livening with HIV know their status, 90% of all those diagnosed receive sustained antiretroviral therapy (ARTs) and 90% all those receiving ARTs will have durable viral suppression. (M170561)
Repo

2017

Developing a Safe and Sustainable Service Delivery Model for Early Infant Male Circumcision (EIMC) in South Africa. Research Report. May 2017(Near to final draft pending NDoH approval). [Pending approval from Funder for publication].

Research Funded by: USAID through a Partnership Cooperative agreement with UNICEF

2016

Dean, G.N., Frade, S., Kopung, M.W.P., Ochere-Darko, J. & Taljaard, D. (2016).

Building a Clinical Profile for a New Voluntary Medical Male Circumcision Surgical Aid Device: A Randomised Control Trial for Building the Clinical Profile for a New VMMC Device Application for Pre-Qualification dossier Phase

1: CircumQ. Johannesburg CHAPS

Dayanund Loykissoonlal, James McIntyre, Dirk Taljaard, Dino Rech, Genevieve N Dean, Sasha Frade, Alexandra Spyrelis, Emmanuel Njeuhmeli, Delivette Castor and Katharine Kripke (2016). Evaluation of the Acceptability and Safety of the PrePex Device Adult Male Circumcision in South Africa: A Pilot Study in Three Clinical Sites

Research Funded by: USAID through ANOVA

2015

Dean, G.N., Frade, S., Mabena, N., Taljaard, D. & Rech, D. (2015). A Case Series Non-Comparative Study in South Africa: CircumQ

2013

Bertrand JT, Rech D, Dickens O, Frade S, Loolpapit M, Machaku MD, Mavhu W, Onyango M, Spyrelis A, Perry L, Farrell-Ross M. (2013). Systematic Monitoring of the Male Circumcision Scale-up in Eastern and Southern Africa (SYMMACS): Final Report of results from Kenya, South Africa, Tanzania, and Zimbabwe. Baltimore: USAID │Project Search: Research to Prevention. 

Research supported by: Johns Hopkins Bloomberg School of Public Health Center for Communication Programs (CCP) and Johns Hopkins Center for Global Health.

Research Funded by: The USAID|Project SEARCH and PEPFAR

Spyrelis A, Frade S, Rech D, & Taljaard D. (2013). Acceptability of Early Infant Male Circumcision in two South African communities. Johannesburg: CHAPS.

Johnson T, Spyrelis A, Frade S, Rech D, & Taljaard D. (2013). Training follow-up study. Johannesburg: CHAPS.

2012

Nieuwoudt S, Frade S, Rech D, & Taljaard D. (2012). Uncovering the “dirt” on Demand Creation for Medical Male Circumcision. Johannesburg: CHAPS

Bertrand JT, Rech D, Dickens O, Frade S, Loolpapit M, Machaku MD, Mavhu W, Perry L & Farrell-Ross M. (2012). Systematic Monitoring of the Male Circumcision Scale-up in Eastern and Southern Africa (SYMMACS): Interim Report of results from Kenya, South Africa, Tanzania, and Zimbabwe. Baltimore: USAID │Project Search: Research to Prevention.

Research supported by: Johns Hopkins Bloomberg School of Public Health Center for Communication Programs (CCP) and Johns Hopkins Center for Global Health.

Research Funded by: The USAID|Project SEARCH and PEPFAR

2011

Rech D, Dickson KE, Samkange C, et al. (2011). Adverse Event Action Guide for Male Circumcision. PSI and WHO: Washington, DC.

2010

World Health Organization. (2010). Considerations for implementing Models for Optimizing the Volume and Efficiency of Male Circumcision Services. Geneva: WHO.

Center for Global Health Policy. (2010). Medical Male Circumcision as HIV Prevention, Follow the Evidence: The case for aggressive scale up. Center for Global Health Policy: Washington, DC.

2009

World Health Organization. (2009). Guidance on engaging volunteers to support the scale up of male circumcision services. Geneva: WHO.

PEPFAR. (2009). PEPFAR Male Circumcision Partner’s Meeting: Commodities and Improved Coordination of Male Circumcision for HIV Prevention. Washington, DC: PEPFAR.

Conference Presentation & Posters

2017

8th SA AIDS CONFERENCE 2017

Sasha Frade, Genevieve Dean, Collen Bonnecwe, Dayanund Loykissoonlal, Doris Macharia, Yin Yin Aung, Sanjana Bhardwaj, Dino Rech, and Dirk Taljaard. (2017). Early Infant Male Circumcision a Sustainable Alternative to VMMC in South Africa. Oral Presentation at 8th SA AIDS CONFERENCE 2017, Durban, 13-15 June 2017.

Sasha Frade, Genevieve Dean, Peter Kopung, Dirk Taljaard. The CircumQ Surgical Aid: Could it increase the acceptability and safety of VMMC in South Africa? Poster Presentation at 8th SA AIDS CONFERENCE 2017, Durban, 13-15 June 2017.

Sasha Frade, Genevieve Dean, Dino Rech, Dirk Taljaard. Clinical Providers Concerns and Perceptions of the PrePex Device: A South African Perspective. Poster Presentation at 8th SA AIDS CONFERENCE 2017, Durban, 13-15 June 2017.

9th IAS Conference on HIV Science (IAS 2017)

Genevieve Dean, Sasha Frade, Dylan Hill, Dirk Taljaard. Not All Mogen Clamps are Created Equal” – Standardising Mogen Clamp Specifications for EIMC. Poster Presentation at the 9th IAS Conference on HIV Science (IAS 2017) Paris, France, 23-26 July 2017

34th ISQua (The International Society for Quality in Health Care) 2017

Genevieve Dean, Sasha Frade, Dino Rech, Dirk Taljaard. The Acceptability of PrePex amongst South African Males.34th ISQua, 2017, Conference, 1-4 October 2017.

2016

21st International AIDS Conference (AIDS 2016)

Dean, G. N., Frade, S., Rech, D., & Taljaard, D. (2016). Clinical outcomes from a pilot study examining the PrePex device for VMMC in South Africa.Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016

Abdulla, S., Frade, S., Ndhlovu, R., Rech, D., & Taljaard, D. (2016). Effectiveness of mobile clinics offering VMMC in marginalised communities as an HIV prevention intervention. Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016

Haté, V., Dean, GN., Frade, S., Rech, D., Taljaard, D., Stegman, P., & Kripke, K. (2016). Does introduction of PrePexTM into an existing surgical VMMC program save money? Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016

Otchere- Darko, J., Monji, L.., Satande, L., Sbu, S., Capati J., & Rech, D. (2016). The impact of clinical associates on expanding high-quality, cost-effective voluntary medical male circumcision (VMMC) services in South Africa. Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016

2015

14th World Conference on Public Health (WCPH), Kolkata, India

Dean, G. N., Frade, S., Spyrelis, A., Abdulla, S., Rech, D., & Taljaard, D. (2015). Cultural and traditional factors affecting the likelihood of parents’ uptake of early infant male circumcision (EIMC) in Soweto and Orange Farm, South Africa. Oral Session presented at the 14th World Conference on Public Health (WCPH), Kolkata, India.

Abdulla, S., Spyrelis, A., Frade, S., Meyer. T., Mhazo. M., Taljaard, D., & Billy, S. (2015). “It’s a good idea and then again it’s not”: The perceived advantages and disadvantages in scaling-up the HIV self-testing kit in Johannesburg, South Africa. Oral Session presented at the 14th World Conference on Public Health (WCPH), Kolkata, India.

2014

Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA

Auvert B, Lissouba P, Taljaard D, Peytavin G, Singh B & Puren A. (2014, March).Male circumcision – Association with HIV prevalence, knowledge, and attitudes among women: Findings from the ANRS 12126 study. Poster session presented at the annual Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA.

2013

South African AIDS Conference (SAAIDS), Durban, South Africa

Frade S, Nieuwoudt S, Rech D, Spyrelis A, & Taljaard D. (2013, June). Culture and tradition as key factors in voluntary medical male circumcision (VMMC) decision-making in Gauteng, South Africa. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.

Spyrelis A, Nieuwoudt S, Frade S, Rech D, & Taljaard D. (2013, June). Peers, sexual partners and family: An exploration of ‘informal’ demand creation in voluntary medical male circumcision (VMMC) in Soweto and Orange Farm, South Africa. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.

Spyrelis A, Frade S, Rech D, Taljaard D, & Bertrand JT. (2013, June). Provider opinions on the voluntary medical male circumcision (VMMC) scale-up in South Africa. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.
S Frade, D Rech, A Spyrelis, M Machaku, W Mavhu, D Omondi, M Onyango, M Farrell-Ross, & J Bertrand. (2013, June). Seasonal patterns in voluntary medical male circumcision (VMMC) in South Africa, Kenya, Tanzania and Zimbabwe. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.
7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia

Rech D, Frade S, Spyrelis A, Perry L, Toledo C, Fertziger R, Njeuhmeli E, & Bertrand JT. (2013, July). Implications of the rapid scale up and the expansion of VMMC in South Africa for quality of services. Paper presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.

Bertrand J, Rech D, Njeuhmeli E, Castor D, Frade S, Loolpapit M, Machaku M, Mavhu W, & Perry L. (2013, July). Determinants of VMMC Provider Burnout in Four Sub-Saharan countries. Poster session presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.

Nieuwoudt S, Frade S, Spyrelis A, Taljaard D, & Rech D. (2013, July). Sexual pleasure, reduced STIs and peer norms: underlying motivations for seeking VMMC in Gauteng, South Africa. Poster session presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.

Rech D, Reed J, Frade S, Samkange CA, Thomas N, Farrell M, Castor D, Njeuhmeli E, & Bertrand J. (2013, July). Efficiencies in the performance of voluntary medical male circumcision (VMMC) procedures. Poster session presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.

2012

XIX International AIDS Conference, Washington DC, USA

Auvert B, Taljaard D, Sitta R, Rech D, Lissouba P, Bouscaillou J, Singh B, Shabangu D, Nhlapo C, Otchere-Darko J, Mashigo T, Taljaard R, Phatedi G, Tsepe M, Chakela M, Mkhwanazi A, Ntshangase P, Peytavin G, Billy S, Puren A, & Lewis D. (2012, July). Decrease of HIV prevalence over time among the male population of Orange Farm, South Africa, following a circumcision roll-out (ANRS-12126). Poster session presented at the 19th International AIDS Conference, Washington, DC, USA.

Taljaard D, Rech D, Frade S, McIntyre J, Struthers H, & Plank R. (2012, July). Feasibility of circumcising male infants in Soweto and Orange Farm, South Africa: Why would parents circumcise their infants? Poster session presented at the 19th International AIDS Conference, Washington, DC, USA.

2009

5th International AIDS Conference on HIV Pathogenesis, Treatment & Prevention

Auvert B, Lissouba P, Cutler E, Zarca K, Puren A, & Taljaard D. (2009, July). Is genital human papillomavirus infection associated with HIV incidence? Paper presented at the 5th International AIDS Conference on HIV Pathogenesis, Treatment and Prevention, Cape Town, South Africa.

Journal Articles

2017

Marshall, E., Rain-Taljaard, R., Tsepe, M., Monkwe, C., Taljaard, D., Hlatswayo, F., Xaba, D., Molomo, T., Lissouba, P., Puren, P., & Auvert, B. (2017). Obtaining a male circumcision prevalence rate of 80% among adults in a short time

An observational prospective intervention study in the Orange Farm township of South Africa. Medicine, 96 (4):e5328.
Maraux, B., Lissouba, P., Rain-Taljaard, P., Taljaard, D., Bouscaillou, J., Lewis, D., Puren, A., Auvert, B. (2017). Women’s knowledge and perception of male circumcision before and after its roll-out in the South African township of Orange Farm from community-based cross-sectional surveys. PLoS One, 12(3): e0173595. https://doi.org/10.1371/journal.pone.0173595

2014

Bertrand JT, Rech D, Omondi Aduda D, Frade S, Loolpapit M, Machaku MD, Onyango M, Mavhu W, Spyrelis A, Perry L, Farrell M, Castor D, & Njeuhmeli E. (2014). Systematic Monitoring of Voluntary Medical Male Circumcision Scale-Up: Adoption of Efficiency Elements in Kenya, South Africa, Tanzania, and Zimbabwe. PLoS One, 9(4): e82518. doi: 10.1371/journal.pone.0082518

Research supported by: Johns Hopkins Bloomberg School of Public Health Center for Communication Programs (CCP) and Johns Hopkins Center for Global Health.

Research Funded by: The USAID|Project SEARCH and PEPFAR
Rech D, Spyrelis A, Frade S, Perry L, Farrell M, Fertziger R, Castor D, Njeuhmeli E, Toledo C, & Bertrand JT. (2014). Implications of the Fast-Evolving Scale-Up of Adult Voluntary Medical Male Circumcision for Quality of Services in South Africa. PLoS One, 9(4):e80577. doi: 10.1371/journal.pone.0080577
Jennings L, Bertrand J, Rech D, Harvey SA, Hatzold K, Samkange CA, Omondi Aduda D, Fimbo B, Cherutich P, Perry L, Castor D, & Njeuhmeli, E. (2014). Quality of Voluntary Medical Male Circumcision Services during Scale-Up: A Comparative Process Evaluation in Kenya, South Africa, Tanzania and Zimbabwe. PLoS One, 9(4): e79524. doi: 10.1371/journal.pone.0079524

Rech D, Bertrand JT, Thomas N, Farrell M, Reed J, Frade S, Samkange C, Obiero W, Agot K, Mahler H, Castor D, & Njeuhmeli E. (2014). Surgical efficiencies and quality in the performance of voluntary medical male circumcision procedures in Kenya, South Africa, Tanzania, and Zimbabwe. PLoS One, 9(4): e84271. doi: 1