CHAPS evolved from the Orange Farm research programme and team that, in the 5 years prior to 2010, had researched and published extensively around the topic of voluntary medical male circumcision. The research and the publications of the Orange Farm team, most notably the randomised controlled trial which demonstrated the 60% protective benefit of medical male circumcision, contributed to the World Health Organization (WHO) recommendations in 2007.

Today, CHAPS is most recognised for its biomedical research and community-based research in the scale-up of voluntary medical male circumcision (VMMC) for HIV prevention in South Africa and the region. However, with both programmatic and research expertise, we are able to offer community-based research and feasibility studies in a number of areas.

Research, Publications And Conference Presentations

2017 

Research Protocols accepted pending Funding

CHAPS Linkage to Care Programme (M170278)
Increasing the uptake of HIV Testing through self-testing kits to ensure that by 2020, 90% of all people livening with HIV know their status, 90% of all those diagnosed receive sustained antiretroviral therapy (ARTs) and 90% all those receiving ARTs will have durable viral suppression. (M170561)
REPORTS

2017

Developing a Safe and Sustainable Service Delivery Model for Early Infant Male Circumcision (EIMC) in South Africa. Research Report. May 2017(Near to final draft pending NDoH approval). [Pending approval from Funder for publication].

Research Funded by: USAID through a Partnership Cooperative agreement with UNICEF

2016

Dean, G.N., Frade, S., Kopung, M.W.P., Ochere-Darko, J. & Taljaard, D. (2016).

Building a Clinical Profile for a New Voluntary Medical Male Circumcision Surgical Aid Device: A Randomised Control Trial for Building the Clinical Profile for a New VMMC Device Application for Pre-Qualification dossier Phase 1: CircumQ. Johannesburg CHAPS

Dayanund Loykissoonlal, James McIntyre,  Dirk Taljaard, Dino Rech, Genevieve N Dean, Sasha Frade, Alexandra Spyrelis, Emmanuel Njeuhmeli, Delivette Castor and Katharine Kripke (2016). Evaluation of the Acceptability and Safety of the PrePex Device  Adult Male Circumcision in South Africa: A Pilot Study in Three Clinical Sites

Research Funded by: USAID through ANOVA

2015

Dean, G.N., Frade, S., Mabena, N., Taljaard, D. & Rech, D. (2015). A Case Series Non-Comparative Study in South Africa: CircumQ

2013

Bertrand JT, Rech D, Dickens O, Frade S, Loolpapit M, Machaku MD, Mavhu W, Onyango M, Spyrelis A, Perry L, Farrell-Ross M. (2013). Systematic Monitoring of the Male Circumcision Scale-up in Eastern and Southern Africa (SYMMACS): Final Report of results from Kenya, South Africa, Tanzania, and Zimbabwe. Baltimore: USAID │Project Search: Research to Prevention. 

Research supported by: Johns Hopkins Bloomberg School of Public Health Center for Communication Programs (CCP) and Johns Hopkins Center for Global Health.

Research Funded by: The USAID|Project SEARCH and PEPFAR

Spyrelis A, Frade S, Rech D, & Taljaard D. (2013). Acceptability of Early Infant Male Circumcision in two South African communities. Johannesburg: CHAPS.
Johnson T, Spyrelis A, Frade S, Rech D, & Taljaard D. (2013). Training follow-up study. Johannesburg: CHAPS.

2012

Nieuwoudt S, Frade S, Rech D, & Taljaard D. (2012). Uncovering the “dirt” on Demand Creation for Medical Male Circumcision. Johannesburg: CHAPS
Bertrand JT, Rech D, Dickens O, Frade S, Loolpapit M, Machaku MD, Mavhu W, Perry L & Farrell-Ross M. (2012). Systematic Monitoring of the Male Circumcision Scale-up in Eastern and Southern Africa (SYMMACS): Interim Report of results from Kenya, South Africa, Tanzania, and Zimbabwe. Baltimore: USAID │Project Search: Research to Prevention.

Research supported by: Johns Hopkins Bloomberg School of Public Health Center for Communication Programs (CCP) and Johns Hopkins Center for Global Health.

Research Funded by: The USAID|Project SEARCH and PEPFAR

2011

Rech D, Dickson KE, Samkange C, et al. (2011). Adverse Event Action Guide for Male Circumcision. PSI and WHO: Washington, DC.

2010

World Health Organization. (2010). Considerations for implementing Models for Optimizing the Volume and Efficiency of Male Circumcision Services. Geneva: WHO.
Center for Global Health Policy. (2010). Medical Male Circumcision as HIV Prevention, Follow the Evidence: The case for aggressive scale up. Center for Global Health Policy: Washington, DC.

2009

World Health Organization. (2009). Guidance on engaging volunteers to support the scale up of male circumcision services. Geneva: WHO.
PEPFAR. (2009). PEPFAR Male Circumcision Partner’s Meeting: Commodities and Improved Coordination of Male Circumcision for HIV Prevention. Washington, DC: PEPFAR.

CONFERENCE PRESENTATIONS & POSTERS

2017

8th SA AIDS CONFERENCE 2017
Sasha Frade, Genevieve Dean, Collen Bonnecwe, Dayanund Loykissoonlal, Doris Macharia, Yin Yin Aung, Sanjana Bhardwaj, Dino Rech, and Dirk Taljaard. (2017). Early Infant Male Circumcision a Sustainable Alternative to VMMC in South Africa. Oral Presentation at 8th SA AIDS CONFERENCE 2017, Durban, 13-15 June 2017.
Sasha Frade, Genevieve Dean, Peter Kopung, Dirk Taljaard. The CircumQ Surgical Aid: Could it increase the acceptability and safety of VMMC in South Africa? Poster Presentation at 8th SA AIDS CONFERENCE 2017, Durban, 13-15 June 2017.
Sasha Frade, Genevieve Dean, Dino Rech, Dirk Taljaard. Clinical Providers Concerns and Perceptions of the PrePex Device: A South African Perspective. Poster Presentation at 8th SA AIDS CONFERENCE 2017, Durban, 13-15 June 2017.
9th IAS Conference on HIV Science (IAS 2017)
Genevieve Dean, Sasha Frade, Dylan Hill, Dirk Taljaard. Not All Mogen Clamps are Created Equal” – Standardising Mogen Clamp Specifications for EIMC. Poster Presentation at the 9th IAS Conference on HIV Science (IAS 2017) Paris, France, 23-26 July 2017
34th ISQua (The International Society for Quality in Health Care)  2017
Genevieve Dean, Sasha Frade, Dino Rech, Dirk Taljaard. The Acceptability of PrePex amongst South African Males.34th ISQua, 2017, Conference, 1-4 October 2017.

2016

21st International AIDS Conference (AIDS 2016)
Dean, G. N., Frade, S., Rech, D., & Taljaard, D. (2016). Clinical outcomes from a pilot study examining the PrePex device for VMMC in South Africa.Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016
Abdulla, S., Frade, S., Ndhlovu, R., Rech, D., & Taljaard, D. (2016). Effectiveness of mobile clinics offering VMMC in marginalised communities as an HIV prevention intervention. Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016
Haté, V., Dean, GN., Frade, S., Rech, D., Taljaard, D., Stegman, P., & Kripke, K. (2016). Does introduction of PrePexTM into an existing surgical VMMC program save money? Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016
Khehla-Adams, A., Rech, D., Maziya, V., & Vandelanotte, J. (2016). Increasing uptake of Circumcision Services among 15-29 old Swazi males through Private Practitioners. Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016
Otchere- Darko, J., Monji, L.., Satande, L., Sbu, S., Capati J., & Rech, D. (2016). The impact of clinical associates on expanding high-quality, cost-effective voluntary medical male circumcision (VMMC) services in South Africa. Poster Presentation Presented at the AIDS 2016 Conference, Durban, 18-22 July 2016

2015

14th World Conference on Public Health (WCPH), Kolkata, India
Dean, G. N., Frade, S., Spyrelis, A., Abdulla, S., Rech, D., & Taljaard, D. (2015). Cultural and traditional factors affecting the likelihood of parents’ uptake of early infant male circumcision (EIMC) in Soweto and Orange Farm, South Africa. Oral Session presented at the 14th World Conference on Public Health (WCPH), Kolkata, India.
Abdulla, S., Spyrelis, A., Frade, S., Meyer. T., Mhazo. M., Taljaard, D., & Billy, S. (2015). “It’s a good idea and then again it’s not”: The perceived advantages and disadvantages in scaling-up the HIV self-testing kit in Johannesburg, South Africa. Oral Session presented at the 14th World Conference on Public Health (WCPH), Kolkata, India.

2014

Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA
Auvert B, Lissouba P, Taljaard D, Peytavin G, Singh B & Puren A. (2014, March).Male circumcision – Association with HIV prevalence, knowledge, and attitudes among women: Findings from the ANRS 12126 study.  Poster session presented at the annual Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA.

2013

South African AIDS Conference (SAAIDS), Durban, South Africa
Frade S, Nieuwoudt S, Rech D, Spyrelis A, & Taljaard D. (2013, June). Culture and tradition as key factors in voluntary medical male circumcision (VMMC) decision-making in Gauteng, South Africa. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.
Spyrelis A, Nieuwoudt S, Frade S, Rech D, & Taljaard D. (2013, June). Peers, sexual partners and family: An exploration of ‘informal’ demand creation in voluntary medical male circumcision (VMMC) in Soweto and Orange Farm, South Africa. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.
Spyrelis A, Frade S, Rech D, Taljaard D, & Bertrand JT. (2013, June). Provider opinions on the voluntary medical male circumcision (VMMC) scale-up in South Africa. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.
S Frade, D Rech, A Spyrelis, M Machaku, W Mavhu, D Omondi, M Onyango, M Farrell-Ross, & J Bertrand. (2013, June). Seasonal patterns in voluntary medical male circumcision (VMMC) in South Africa, Kenya, Tanzania and Zimbabwe. Poster session presented at the 6th South African AIDS Conference (SAAIDS), Durban, South Africa.
7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia
Rech D, Frade S, Spyrelis A, Perry L, Toledo C, Fertziger R, Njeuhmeli E, & Bertrand JT. (2013, July). Implications of the rapid scale up and the expansion of VMMC in South Africa for quality of services. Paper presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.
Bertrand J, Rech D, Njeuhmeli E, Castor D, Frade S, Loolpapit M, Machaku M, Mavhu W, & Perry L. (2013, July). Determinants of VMMC Provider Burnout in Four Sub-Saharan countries. Poster session presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.
Nieuwoudt S, Frade S, Spyrelis A, Taljaard D, & Rech D. (2013, July). Sexual pleasure, reduced STIs and peer norms: underlying motivations for seeking VMMC in Gauteng, South Africa. Poster session presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.
Rech D, Reed J, Frade S, Samkange CA, Thomas N, Farrell M, Castor D, Njeuhmeli E, & Bertrand J. (2013, July). Efficiencies in the performance of voluntary medical male circumcision (VMMC) procedures. Poster session presented at the 7th International AIDS Conference (IAS), Kuala Lumpur, Malaysia.

2012

XIX International AIDS Conference, Washington DC, USA
Auvert B, Taljaard D, Sitta R, Rech D, Lissouba P, Bouscaillou J, Singh B, Shabangu D, Nhlapo C, Otchere-Darko J, Mashigo T, Taljaard R, Phatedi G, Tsepe M, Chakela M, Mkhwanazi A, Ntshangase P, Peytavin G, Billy S, Puren A, & Lewis D. (2012, July). Decrease of HIV prevalence over time among the male population of Orange Farm, South Africa, following a circumcision roll-out (ANRS-12126). Poster session presented at the 19th International AIDS Conference, Washington, DC, USA.

Taljaard D, Rech D, Frade S, McIntyre J, Struthers H, & Plank R. (2012, July). Feasibility of circumcising male infants in Soweto and Orange Farm, South Africa:  Why would parents circumcise their infants? Poster session presented at the 19th International AIDS Conference, Washington, DC, USA.

2009

5th International AIDS Conference on HIV Pathogenesis, Treatment & Prevention
Auvert B, Lissouba P, Cutler E, Zarca K, Puren A, & Taljaard D. (2009, July). Is genital human papillomavirus infection associated with HIV incidence? Paper presented at the 5th International AIDS Conference on HIV Pathogenesis, Treatment and Prevention, Cape Town, South Africa.

JOURNAL ARTICLES

2017

Marshall, E., Rain-Taljaard, R., Tsepe, M., Monkwe, C., Taljaard, D., Hlatswayo, F., Xaba, D., Molomo, T.,  Lissouba, P., Puren, P., & Auvert, B. (2017). Obtaining a male circumcision prevalence rate of 80% among adults in a short time

An observational prospective intervention study in the Orange Farm township of South Africa. Medicine, 96 (4):e5328.

Maraux, B., Lissouba, P., Rain-Taljaard, P., Taljaard, D., Bouscaillou, J., Lewis, D., Puren, A., Auvert, B. (2017). Women’s knowledge and perception of male circumcision before and after its roll-out in the South African township of Orange Farm from community-based cross-sectional surveys. PLoS One, 12(3): e0173595. https://doi.org/10.1371/journal.pone.0173595

2014

Bertrand JT, Rech D, Omondi Aduda D, Frade S, Loolpapit M, Machaku MD, Onyango M, Mavhu W, Spyrelis A, Perry L, Farrell M, Castor D, & Njeuhmeli E. (2014). Systematic Monitoring of Voluntary Medical Male Circumcision Scale-Up: Adoption of Efficiency Elements in Kenya, South Africa, Tanzania, and Zimbabwe. PLoS One, 9(4): e82518. doi: 10.1371/journal.pone.0082518

Research supported by: Johns Hopkins Bloomberg School of Public Health Center for Communication Programs (CCP) and Johns Hopkins Center for Global Health.

Research Funded by: The USAID|Project SEARCH and PEPFAR

Rech D, Spyrelis A, Frade S, Perry L, Farrell M, Fertziger R, Castor D, Njeuhmeli E, Toledo C, & Bertrand JT. (2014). Implications of the Fast-Evolving Scale-Up of Adult Voluntary Medical Male Circumcision for Quality of Services in South Africa. PLoS One, 9(4):e80577. doi: 10.1371/journal.pone.0080577
Jennings L, Bertrand J, Rech D, Harvey SA, Hatzold K, Samkange CA, Omondi Aduda D, Fimbo B, Cherutich P, Perry L, Castor D, & Njeuhmeli, E. (2014). Quality of Voluntary Medical Male Circumcision Services during Scale-Up: A Comparative Process Evaluation in Kenya, South Africa,

Tanzania and Zimbabwe. PLoS One, 9(4): e79524. doi: 10.1371/journal.pone.0079524

Rech D, Bertrand JT, Thomas N, Farrell M, Reed J, Frade S, Samkange C, Obiero W, Agot K, Mahler H, Castor D, & Njeuhmeli E. (2014). Surgical efficiencies and quality in the performance of voluntary medical male circumcision procedures in Kenya, South Africa, Tanzania, and

Zimbabwe. PLoS One, 9(4): e84271. doi: 10.1371/journal.pone.0084271

Perry L, Rech D, Mavhu W, Frade S, Machaku MD, Onyango M, Omondi Aduda D, Fimbo B, Cherutich P, Castor D, Njeuhmeli E, & Bertrand JT. (2014). Work Experience, Job-Fulfillment and Burnout among VMMC Providers in Kenya, South Africa, Tanzania and Zimbabwe. PLoS One, 9(4):

e84215. doi: 10.1371/journal.pone.0084215

Mavhu W, Frade S, Yongho AM, Farrell M, Hatzold K, Machaku M, Onyango M, Mugurungi O, Fimbo B, Cherutich P, Rech D, Castor D, Njeuhmeli E, & Bertrand JT. (2014). Provider Attitudes toward the Voluntary Medical Male Circumcision Scale-Up in Kenya, South Africa, Tanzania and Zimbabwe. PLoS One, 9(4):

e82911. doi: 10.1371/journal.pone.0082911

2013

Auvert B, Taljaard D, Rech D, Lissouba P, Singh B, Bouscaillou J, Peytavin G, Mahiane SG, Sitta R, Puren A, & Lewis D. (2013). Association of the ANRS-12126 Male Circumcision Project with HIV Levels among Men in a South African Township: Evaluation of Effectiveness using Cross-sectional Surveys. PLoS Med, 10(9): e1001509. d
2012
Venter, F., Rees, H., Pillay, Y., Simelela, N., Mbengashe, T. M., Geffen, N., Conradie, F., Shisana, O., Rech, D., Serenata, C., Taljaard, D. & Gray, G. (2012). The medical proof doesn’t get much better than VMMC. South African Medical Journal, 102, 124-6.

2011

Lissouba P, Taljaard D, Rech D, Dermaux-Msimang V, Legeai C, Lewis D, Singh B, Puren A, & Auvert B. (2011). Adult male circumcision as an intervention against HIV: an operational study of uptake in a South African community (ANRS 12126).  BMC Infectious Diseases, 11: 253, doi: 10.1186/1471-2334-11-253
Tarnaud C, Lissouba P, Cutler E, Puren A, Taljaard D, & Auvert B. (2011). Association of low-risk human papillomavirus infection with male circumcision in young men: Results from a longitudinal study conducted in Orange Farm (South Africa). Infectious Diseases in Obstetrics and Gynaecology, 567408. doi: 10.1155/2011/567408.
Edgil D, Stankard P, Forsythe S, Rech D, Chrouser K, Adamu T, Sakallah S, Thomas AG, Albertini J, Stanton D, Dickson KE, & Njeuhmeli E. (2011). Voluntary medical male circumcision: Logistics, commodities, and waste management requirements for scale-up of services. PloS Med, 8(11): e1001128. doi: 10.1371/journal.pmed.1001128

2010

Lissouba P, Taljaard D, Rech D, Doyle S, Shabangu D, Nhlapo C, Otchere-Darko J, Mashigo T, Matson C, Lewis D, Billy S, & Auvert, B. (2010). A model for the roll-out of comprehensive adult male circumcision services in African low-income settings on high HIV incidence: the ANRS 12126 Bophelo Pele Project. PLoS Med 7(7):e1000309.
Fiamma A, Lissouba P, Amy OE, Singh B, Laeyendecker O, Quinn TC, Taljaard D, & Auvert B. (2010). Can HIV incidence testing be used for evaluating HIV intervention programs? A reanalysis of the Orange Farm male circumcision trials (ANRS-1265). BMC Infectious Diseases, 10:137. doi: 10.1186/1471-2334-10-137.
Auvert B, Lissouba P, Cutler E, Zarca K, Puren A, & Taljaard D. (2010). Association of oncogenic and nononcogenic human papillomavirus with HIV incidence. Journal of Acquired Immune Deficiency Syndrome, 53(1):111-6. doi: 10.1097/QAI.0b013e3181b327e7.
2009
Mehta SD, Gray RH, Auvert B, Moses S, Kigozi G, Taljaard D, Puren A, Agot K, Serwadda D, Parker CB, Wawer MJ, & Bailey RC. (2009). Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials. AIDS, 23(12):1557-64. doi: 10.1097/QAD.0b013e32832afe95
Lagarde E, Taljaard D, Puren A, & Auvert B. (2009). High rate of adverse events following circumcision of young male adults with the Tara Klamp technique: A randomised trial in South Africa. South African Medical Journal, 99 (3):163-9.
Auvert B, Lissouba P, Taljaard D, Geffen N, Fiamma A, & Heywood M. (2009). Key facts on male circumcision. South African Medical Journal, 99(3):150-1.
Sobngwi-Tambekou J, Taljaard D, Lissouba P, Zarca K, Puren A, Lagarde E, & Auvert B. (2009). Effect of HSV-2 serostatus on acquisition of HIV by young men: results of a longitudinal study in Orange Farm, South Africa. Journal of Infectious Diseases, 199(7):958-64. doi: 10.1086/597208.
Mahiane SG, Legeai C, Taljaard D, Latouche A, Puren A, Peillon A, Bretagnolle J, Lissouba P, Nguema EP, Gassiat E, & Auvert B. (2009). Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: A longitudinal study in a township of South Africa. AIDS, 23(3):377-383.
Auvert B, Sobngwi-Tambekou J, Cutler E, Nieuwoudt M, Lissouba P, Puren A, & Taljaard D. (2009). Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: Results of a randomized controlled trial conducted in Orange Farm, South Africa. Journal of Infectious Diseases, 199(1):14-9. doi: 10.1086/595566.
Sobngwi-Tambekou J, Taljaard D, Nieuwoudt M, Lissouba P, Puren A, & Auvert B. (2009). Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention. Sexually Transmitted Infections, 85(2):116-20. doi: 10.1136/sti.2008.032334.

2008

Auvert B, Marseille E, Korenromp EL, Lloyd-Smith J, Sitta R, Taljaard D, Pretorius C, Williams B, & Kahn JG. (2008). Estimating the resources needed and savings anticipated from roll-out of adult male circumcision in Sub-Saharan Africa. PLoS One, 3(8):e2679. doi: 10.1371/journal.pone.0002679.

2007

Lagarde E, Taljaard D, Puren A, Shilaluke G, Gwala B, & Zulu D, Gumede G, & Auvert B. (2007).Safety of a disposable male circumcision kit. Results from a randomized controlled trial conducted in South Africa. African Journal of Urology, 13(1), 17–29.

2005

Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, & Puren A. (2005). Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 trial. PLoS Med, 2(11):e298.

2004

Auvert B, Males S, Puren A, Taljaard D, Caraël M, & Williams B. (2004). Can highly active antiretroviral therapy reduce the spread of HIV? A study in a township of South Africa. Journal of Acquired Immune Deficiency Syndrome, 36(1):613-21.

2003

Williams BG, Taljaard D, Campbell CM, Gouws E, Ndhlovu L, Van Dam J, Caraël M, & Auvert B. (2003). Changing patterns of knowledge, reported behaviour and sexually transmitted infections in a South African gold mining community. AIDS, 17(14):2099-107.
Lagarde E, Taljaard D, Puren A, Taljaard R, & Bertran A. (2003). Acceptibility of male circumcision as a tool for preventing HIV infection in a highly infected community in South Africa. AIDS, 17(1), 89-95.

2001

Auvert B, Ballard R, Campbell C, Caraël M, Carton M, Fehler G, Gouws E, MacPhail C, Taljaard D, Van Dam J, & Williams B. (2001). HIV infection among youth in a South African mining town is associated with herpes simplex virus-2 seropositivity and sexual behaviour. AIDS, 15(7):885-98.

For more information on our research-related services, email Genevieve Dean on gen@chaps.org.za